factor xiiia การใช้

• Factor XIII is activated by thrombin into factor XIIIa; its activation into Factor XIIIa requires cofactor.
• Factor XIII is activated by thrombin into factor XIIIa; its activation into Factor XIIIa requires cofactor.
• Factor XIIIa is a transglutaminase that catalyzes the formation of covalent bonds between lysine and glutamine residues in fibrin.
• Upon activation by thrombin, factor XIIIa acts on fibrin to form ?-glutamyl--lysyl amide cross links between fibrin molecules to form an insoluble clot.
• This peptide is composed of heparin binding domain and transglutaminase substrate domain which can be cross-linked into the fibrin matrix by polymerization via transglutaminase activity of factor XIIIa.
• He is currently carrying out projects for the identification of homing peptides to tumor and atherosclerotic plaque and of phosphatidylserine-and blood clotting factor XIIIa-specific peptide ligands.
• Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII . This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot.
• Cells expressing CD34 ( CD34 + cell ) are normally found in the umbilical cord and bone marrow as hematopoietic cells, a subset of mesenchymal stem cells, endothelial progenitor cells, endothelial cells of blood vessels but not lymphatics ( except pleural lymphatics ), mast cells, a sub-population dendritic cells ( which are factor XIIIa-negative ) in the interstitium and around the MPNSTs, etc . The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes.